GhostReader™
GhostReader™ is a document and selection reader often used by people with dyslexia, by students for language learning and by people who prefer to listen to text rather than read it. GhostReader can read Text, Word, HTML, PDF and RTF documents (plus in Leopard: DOCX and ODT documents) and selected text in almost any application.
Origin Instruments no longer sells GhostReader. It is a product of Assistiveware and can be found on the Apple app store.